Chlorpromazine: Inhibition of ACTH and cyclic 3′,5′-AMP stimulated corticosterone synthesis

Ajai Haksar,Fernand G Pdron

doi:10.1016/s0006-291x(71)80238-3

Chlorpromazine: Inhibition of ACTH and cyclic 3′,5′-AMP stimulated corticosterone synthesis

Ajai Haksar, Fernand G Pdron

https://doi.org/10.1016/s0006-291x(71)80238-3

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Journal: Biochemical and Biophysical Research Communications	Publication Date: Sep 1, 1971
Citations: 8

#Cyclic AMP Stimulation #AMP Stimulated + Show 8 more

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Abstract

Chlorpromazine inhibits the ACTH and cyclic AMP-stimulated corticosterone synthesis, invitro, in the quartered rat adrenal glands without greatly affecting the basal production of corticosterone. Tissues exposed for 30 minutes to cyclic AMP do not show inhibition of cyclic AMP stimulation by chlorpromazine and the removal of chlorpromazine from the incubation medium restores the tissue response to cyclic AMP.

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