Abstract
Chloroquine inhibits sexual cell fusion and macrocyst formation in heterothallic Dictyostelium discoideum in a dose-dependent manner. As judged by cell morphology, the effect of chloroquine is not due to nonspecific toxicity, and normal macrocyst development ensues upon the removal of the drug. The mode of action of chloroquine on both receptor recycling and protease activity is discussed in terms of current knowledge of sexual cell fusion in D. discoideum.
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