Abstract
Chloroquine given intravenously in two patients with auricular fibrillation produced identical cardiac effects. Fibrillation changed to flutter, but with further injection ventricular premature beats and short periods of ventricular tachycardia appeared. Slowing of the auricular rate appears to be due to a vagolytic action of the drug similar to quinidine. The effect of stimulation of ectopic impulse formation also resembles that noticed sometimes with quinidine, mainly in cases of auricular fibrillation.
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