Abstract
Can we understand how plant cell metabolism really works? An integrated large-scale modelling of plant metabolism predictive model would make possible to analyse the impact of disturbances in environmental conditions on cellular functioning and diversity of plant-made molecules of interest. ChloroKB, a Web application initially developed for exploration of Arabidopsis chloroplast metabolic network now covers Arabidopsis mesophyll cell metabolism. Interconnected metabolic maps show subcellular compartments, metabolites, proteins, complexes, reactions, and transport. Data in ChloroKB have been structured to allow for mathematical modelling and will be used as a reference for modelling work dedicated to a particular issue.
Highlights
Will we one day be able to model plant metabolism as we can model the flight of an aircraft? Beyond the obvious advantage of large-scale modelling of plant metabolism for the optimised production of molecules of interest, for example, having an integrated predictive model at our disposal would allow us to totally change the way we can validate our knowledge
It would be possible to analyse the impact of disturbances in environmental conditions on cellular functioning, an essential preliminary step for a detailed understanding of how plants live in their environment
The task seems immense because plant cell metabolism is certainly the most complex eukaryotic metabolism to understand given the nature of the energy source used and the existence of an additional compartment that uses and controls this energy
Summary
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