Abstract
Nickel-induced contact dermatitis is a severe allergic reaction to objects or environments that contain nickel. Many nanomaterials have been developed to reduce skin allergies by capturing nickel, but few agents are effective and safe. In this work, mesoporous silica nanoparticles (MSN) were synthesized and decorated with hexa-histidine peptides (denoted as MSN-His6), making it a strong nickel chelator. Subsequently, a dietary polyphenol, chlorogenic acid, was loaded into the mesopores of MSN (denoted as MSN-His6@CGA), realizing the potential of its anti-inflammatory properties. In vitro and in vivo experiments revealed that the synthesized MSN-His6@CGA nanoparticles exhibited more stable and stronger chelation, better biocompatibility, and ideal allergy-relieving ability, whether for environmental metal contamination or for allergic contact dermatitis caused by prolonged nickel exposure. Thus, the application of mesoporous silica-based nanoparticles may represent an ideal approach to alleviate skin allergies by capturing nickel, which would benefit people who suffer from metal-induced contact dermatitis.
Highlights
Allergic contact dermatitis (ACD) is the most common disease in dermatology
Nickel ions are solubilized from nickel-containing cosmetics or jewelry by sweat, and subsequently serve as allergens that percutaneously invade the stratum corneum barrier, which is the water-impermeable outer layer of the skin
Once metal ions come into contact with pattern-recognition receptors (PRRs), an inappropriate immune response is initiated, leading to the antigen-presenting function of resident dendritic cells and Langerhans cells, the generation of allergen-specific T-cells, and lymphocyte activation
Summary
Allergic contact dermatitis (ACD) is the most common disease in dermatology. There are three types of contact dermatitis, including irritant contact dermatitis, ACD, and photocontact dermatitis in clinic [1]. An ideal preventive treatment for nickel-induced contact dermatitis is a skin toner that can be applied to effectively capture nickel or two other valence metal ions in a short time, with high absorption, low toxicity, and immunogenicity Inorganic materials, such as porous silica nanoparticles, have attracted our attention, limited in the chemistry industry, and in healthcare, medical applications, and cosmetics [8,9,10,11]. Our results showed that hexa-histidine peptide-functionalized MSN exhibited a s3troofn1g2 absorption capacity, better biocompatibility and more stable chelation, whether for environmental metal contamination or for allergic contact dermatitis caused by prolonged pmreesteanl tiothneeaxnptoibsuacrtee,raianldacthtieviitdyeoafl CMGSAN--lHoaids6eaddMsoSrNbetnhtrolouagdhetdhewaitchcuamnualtautrioanl coofmrepaocutinvde olexaydgienngstpoetchieese[f2fe7c].t of interest has potential application prospects.
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