Abstract
Chloroacetylchloride is widely used in organic synthesis as a bifunctional reagent because acyl chloride (hard electrophile) easily forms esters [¹] or amides, [²-4] while the other end the chloromethyl site (soft electrophile) can form other linkages. [²-7] It is a convenient reagent for the preparation of heterocyclic compounds and is utilized as an important building block in the synthesis of natural and therapeutically active compounds. [¹0] [¹¹]
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