Chloride intracellular channel protein 1 expression in normal and atherosclerotic human arteries. Challenges for a new therapeutic target in atheromatosis.

Abstract

Background and Aims: Chloride intracellular ion channel protein 1 (CLIC1) is involved in inflammation from various disease and oxidative stress endothelial cells disfunction. Its role in atherosclerosis is scarcely suggested in the literature, being restricted to experimental induced atherosclerosis in mice. Its involvement in human atheroma plaque formation is completely unknown in this moment. AIM.To study CLIC1 expression in normal human fetal and adult aorta, on early steps of atheroma plaque development and also in complicated atherosclerotic lesions.