Abstract
<i>In Reply</i>.—We agree with Green and MacKeen that drug contact time with the eye following topical administration is important for drug penetration,<sup>1</sup>and that the surface epithelium of the eye acts as a reservoir for drug storage, as well as a barrier to drug penetration.<sup>2</sup>We do not agree that a comparison between their study, where a 50 μl drop of chloramphenicol solution was placed in the eye and the lids were held apart to form a reservoir for up to four hours,<sup>1</sup>can be made with our study, where 50 μl of ointment was placed in the eye and the eye was bandaged.<sup>3</sup>We interpreted the 50-μl drop in the held open eye as bathing because the normal rabbit (and man<sup>4</sup>) lacrimal fluid volume is 7.5 ± 2.5 μl.<sup>5</sup>Only a fraction of this 7.5 μl would remain after 30 minutes of
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