Abstract
The extensive field trial of chloramphenicol (chloromycetin®) in the treatment of scrub typhus (tsutsugamushi fever), which was carried on in the Federation of Malaya during 1948 by the United States Army Medical Research Unit, 1 furnished an opportunity to add to our earlier, limited studies 2 on the therapeutic efficacy of this new antibiotic in patients with murine (endemic) typhus. Since murine typhus occurs frequently in the southern part of the United States, 3 it seems worth while to report the beneficial results obtained with chloramphenicol in this disease. MATERIALS AND METHODS Chloramphenicol.— The antibiotic, prepared by a fermentation process, was supplied by Parke, Davis & Company in the form of compressed 0.1 and 0.25 Gm. tablets suitable for oral use. Selection of Patients.— During the period March through May, 1948, 7 patients with murine typhus were observed who contracted their illness in the vicinity of Kuala Lumpur, Federation of
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