Abstract
The genus of Chlamydiae comprises obligate intracellular pathogens that occasionally can disseminate and even cause septic infections. Chlamydophila pneumoniae causes acute and chronic respiratory tract infections from sinusitis to severe pneumonia, and phagocytes can transmit the bacteria from the lungs to the vasculature. We have previously shown in IL-10 knockout mice that IL-10 limits the severity of inflammation but prolongs the clearance of the C. pneumoniae pneumonia [1].
Highlights
In 2002, the Surviving Sepsis Campaign defined a strategy that aimed to reduce the high mortality due to sepsis
For example at 5 μg/ml LPS, the expression of GIPR was reduced to 86% and INSR 72% of control in U937: while in HUH7 cells at 1 μg/ml LPS, the GIPR expression was decreased to 63%, GLP-1R 95% and INSR 89% compared with control (P
As a result of this study we have developed a standardized sepsis protocol to integrate into the AE triage pro forma, as well as a pathway to help instigate treatment earlier to those patients identified as septic on the wards
Summary
In 2002, the Surviving Sepsis Campaign defined a strategy that aimed to reduce the high mortality due to sepsis. Patients admitted to ICUs with severe sepsis have a 39.8% risk of death [2], and for each hour delay in antibiotic administration, a 7.6% increase in mortality [3]. The objective of the present study was to evaluate the impact of early fluid resuscitation on serial TNFα and IL-6 levels and its association with mortality in severe sepsis. Our laboratory has demonstrated in preliminary clinical studies among the various biomarkers of endothelial dysfunction that blood levels of endocan (ESM-1), a pulmonary vascular endothelial cell-specific molecule participating in the control of endothelial–leukocyte interactions, are associated with the severity and evolution of septic states. The objective, of our study was to predict the development of organ failure at 24 hours using only the data available from the first 4 hours post inoculation Methods This pneumonia-sepsis model included 19 sheep with ALI. The sera were analyzed through serological (IgM and IgG specific ELISA) and molecular (gel-based and real-time RT-PCR) testing
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