Year-end Sale % OFF 
Abstract
During ciliogenesis, centrioles convert to membrane-docked basal bodies, which initiate the formation of cilia/flagella and template the nine doublet microtubules of the flagellar axoneme. The discovery that many human diseases and developmental disorders result from defects in flagella has fueled a strong interest in the analysis of flagellar assembly. Here, we will review the structure, function, and development of basal bodies in the unicellular green alga Chlamydomonas reinhardtii, a widely used model for the analysis of basal bodies and flagella. Intraflagellar transport (IFT), a flagella-specific protein shuttle critical for ciliogenesis, was first described in C. reinhardtii. A focus of this review will be on the role of the basal bodies in organizing the IFT machinery.
Highlights
Cilia and flagella are thread-like cell extensions
The four fibers are interconnected as composition of the flagellar basal apparatus of C. reinhardtii, analyze the development of basal bodies indicated by the green shaded area
In bld2-1, of Bld12p/SAS6 and the pinheads of the cartwheel are composed of Bld10p/CEP135 mutants of ε-tubulin, bodies consist of a ring of singlet microtubules and flagella are absent. uni3-1
Summary
Cilia and flagella (terms referring essentially to the same cell organelles) are thread-like cell extensions. Reinhardtii, and numerous mutants with defects in basal body asbasal organizing for the for cell’s This is apparent in flagellate protists structure, number, position and function have been identified (Figure 2). Neither flagella nor basal bodies are essential for C. reinhardtii, and numerous mutants with defects in basal body structure, basal bodies, the probasal bodies (proBB3) and the microtubular roots consisting of 2 (2MT) or 4 number, position and function have been identified (Figure 2). The four fibers are interconnected as composition of the flagellar basal apparatus of C. reinhardtii, analyze the development of basal bodies indicated by the green shaded area. (darkbasal blue) and the pinheads of the cartwheel are composed of Bld10p/CEP135 mutants of ε-tubulin, bodies consist of a ring of singlet microtubules and flagella are absent. For the distribution of cells with 0–4 flagella are based on Kuchka and Jarvik, 1982
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
