Chlamydia trachomatous antibodies cross reaction with seropositive Toxoplasma gondii and Cytomegalovirus among women with abortion and outcomes of congenital abnormalities in Kirkuk City

Abstract

From 1st Jan2009 to31th of Dec 2009 a total of 1406 women sera with abortions and outcomes of congenital abnormalities in Kirkuk city were screened for infections like Chlamydia trachomatis, Toxoplasma gondii and cytomegalovirus (CMV).These agents were determined in sera using commercial Elisa diagnostic kits.
 Results of the study showed that CMV infection was more prevalent 39.74 % followed by Toxoplasmosis 16.37 %and Chlamydial infection 14.67 %.High rates of Toxoplasmosis and CMV were recorded among women aging from 15 to 25 year, while high of Chlamydial infection was recorded among women aging 26 to 35 years P<0.05. Sera of non-pregnant women reveal high rate of Chlamydial infection, while toxoplasmosis and CMV were exert in sera of pregnant women. High rates of IgM antibodies 8.33 %and 11.41 % were recorded with CMV and Chlamydia respectively compare to 3.84 % for toxoplasmosis ,P<0.05. Cross reactions rate among three microorganisms were detected in 29 sera with the rate 2.52 %, which divided in to 2.10 % for Chlamydia pulse Toxoplasma and 0.69 % for Chlamydia pulse CMV. Two serum samples show 0.54% of mixed IgM antibodies of Chlamydia, toxoplasma, CMV and rubella, the rate was 0.14 %.
 Conclusion: The present study demonstrates a strong association between the infectious agents (Chlamydia, Toxoplasma and CMV) and women abortion and congenital outcomes. It is therefore recommended that all antenatal cases with such history should be routinely screened for these agents. Chlamydia IgM test should be added to preventive tests prior to marriage and parallel to toxoplasma test, CMV and rubella during screening for women abortion and congenital anomalies.