Abstract
ObjectiveTo determine whether IgG antibodies to Chlamydia pneumoniae are associated with nonarteritic ischemic optic neuropathy (NAION). DesignRetrospective case-control study. ParticipantsThe study cohort consisted of 71 consecutive patients with NAION and 71 controls matched for age and gender. Main outcome measuresSerum immunoglobulin G (IgG) antibody titers to Chlamydia pneumoniae. ResultsPatients with NAION had significantly higher IgG antibody titers to C. pneumoniae compared with control subjects (IgG titer ≥1:128: 29 patients versus 15 controls, P = 0.017). The odds ratio for patients with an IgG titer ≥1:128 was 2.56 (95% confidence interval [CI], 1.2–5.5). Adjustment for arterial hypertension, diabetes mellitus, and myocardial infarction resulted in an odds ratio of 3.48 (95% CI, 1.3–9.6). ConclusionsOur results suggest that elevated titers of IgG antibodies to C. pneumoniae are associated with NAION.
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