Abstract
Lung cancer represents a complex and malignant cancer. Close Homologue of L1 (CHL1) gene plays a crucial role in the progress of cancer. The aim of this study is to explore the association between CHL1 rs425366 polymorphism and lung cancer susceptibility in northeast of China. A hospital-based case-control study was carried out to collect relative characteristics. Logistic regression analysis was conducted to analyze the relationship between single nucleotide polymorphisms and lung cancer susceptibility. The results suggested that there was statistically significant difference between GT genotype and TT genotype of rs425366 and lung cancer susceptibility. In stratified analysis, TT genotype of rs425366 may increase the risk of lung adenocarcinoma. We also found that non-smoking individuals carrying T allele were more likely to develop lung cancer. Overall, our study may indicate that CHL1 gene may increase lung cancer susceptibility in northeast of China.
Highlights
Lung cancer is one of the complicated and malignant diseases, causing 1.8 million new cases and 1.6 million deaths annually in the worldwide [1,2,3]
The aim of this study is to explore the association between Close Homologue of L1 (CHL1) rs425366 polymorphism and lung cancer susceptibility in northeast of China
Gene polymorphism and environmental factors play key roles in lung cancer initiation and progression. We performed this case-control study to estimate the connection between CHL1 gene polymorphism and lung cancer susceptibility
Summary
Lung cancer is one of the complicated and malignant diseases, causing 1.8 million new cases and 1.6 million deaths annually in the worldwide [1,2,3]. In China, the increase of lung cancer hits 1.63% per year, 1.30% for men and 2.34% for women [4, 5]. In spite of significant breakthrough in the treatment of lung cancer, 5-year survival rate still remains less than 10% [6, 7]. As the research moved along, tobacco exposure was considered as one of the potential risk factors for lung cancer [8,9,10,11]. There are still a large proportion of non-smoking patients suffering from lung cancer in their lifetime [12]. Gene polymorphisms and environmental factors play prominent roles in the process of cancer occurrence, progression and treatment [13, 14]
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