Abstract
Passive commercial gauzes were turned into interactive wound dressings by impregnating them with a chitosan suspension. To further improve healing, and cell adhesion and proliferation, chitosan/bioactive glass wound dressings were produced with the addition of (i) 45S5, (ii) a Sr- and Mg-containing bioactive glass, and (iii) a Zn-containing bioactive glass to the chitosan suspension. SEM and FTIR analyses evidenced positive results in terms of incorporation of bioactive glass particles. Bioactivity was investigated by soaking chitosan-based bioactive glass wound dressings in simulated body fluid (SBF). Cell viability, proliferation, and morphology were investigated using NIH 3T3 (mouse embryonic fibroblast) cells by neutral red (NR) uptake and MTT assays. Furthermore, the wound-healing rate was evaluated by means of the scratch test, using NIH 3T3. The results showed that bioactive glass particles enhance cell adhesion and proliferation, and wound healing compared to pure chitosan. Therefore, chitosan-based bioactive glass wound dressings combine the properties of the organic matrix with the specific biological characteristics of bioactive glasses to achieve chitosan composites suitable for healing devices.
Highlights
In recent years, with the increase in diabetic problems, scientists have been exploring different materials for the treatment of wounds from natural and synthetic sources [1]
The healing process comprises a precise sequence of harmonized steps in which migratory and resident cell populations, components of the extracellular matrix, and soluble mediators are involved [6]
To ascertain that bioactive glass particles were embedded into wound dressings, SEM analyses beforeTo immersion
Summary
With the increase in diabetic problems, scientists have been exploring different materials for the treatment of wounds from natural and synthetic sources [1]. An ideal wound dressing should maintain wound moisture, protect wounds from environmental discomfort and bacteria, adsorb exudates, and enhance healing. An ideal wound dressing should be readily available, economic, and should be removed without pain for the patient. The regeneration of wound tissue is a complicated process that involves blood clotting, epithelialization, wound contraction, and synthesis of collagen and blood vessels [2,3,4,5]. The healing process comprises a precise sequence of harmonized steps in which migratory and resident cell populations, components of the extracellular matrix, and soluble mediators are involved [6]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
