Abstract
The effect of chitosan addition on the structure and drug release properties of ureasil–polyethylene oxide (U–PEO) hybrid materials was examined. The hybrids and the blends were prepared by the sol–gel route and their structural features were characterized by infrared spectroscopy, differential scanning calorimetry, X-ray powder diffraction, and small angle X-ray scattering. The different characterization techniques revealed the formation of transparent, rubbery, flexible, water-insoluble, and low crystalline chitosan/(U–PEO hybrid) blends, which could easily dissolve pramoxine (used as a model drug). The results showed that the combined addition of chitosan and pramoxine improved the compatibility of the organic and inorganic components of the U–PEO matrix, and provided a means of tailoring the amount of drug released at steady state equilibrium.
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