Abstract
Handling wound-related infections represent major challenges among traditional and modern medical practitioners since bacteria can easily invade the tissues and proliferate, hampering the regeneration process. Hence highly efficient photosensitizers (PS) for antimicrobial photodynamic therapy (APDT) that are able to prevent infection and promote wound healing have been extensively explored in this regard. Chitosan -porphyrin composite (CPC) as a new PS for APDT were synthesis by immobilized porphyrins with different functional groups on chitosan. The structural characterization of the newly obtained PS confirmed the success of the porphyrin immobilization on the solid supports. Their photodynamic efficacy were evaluated and the results indicated that silver meso-tetra (4-methoxylphenyl) porphyrin-chitosan composite (C-AgTMPP) and silver meso-tetra (4-hydroxylphenyl) porphyrin-chitosan composite (C-AgTHPP) have the most favourable antibacterial activity against all bacterial isolates however, majority of the composites demonstrate no significant antimicrobial activity at low concentration.
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