Abstract
The ionic gelation process for the synthesis of chitosan nanoparticles was carried out in microdroplet reactions. The synthesis could be stopped instantaneously at different time points by fast dilution of the reaction mixture with DI water. Using this simple technique, the effect of temperature and reactant concentrations on the size and distribution of the nanoparticles formed, as a function of time, could be investigated by DLS and SEM. Results obtained indicated very early (1–5 s) nucleation of the particles followed by growth. The concentration of reactants, reaction temperature as well as time, were found to (severally and collectively) determine the size of nanoparticles and their distribution. Nanoparticles obtained at 4 °C were smaller (60–80 nm) with narrower size distribution. Simulation experiments using Comsol software showed that at 4 °C ‘droplet synthesis’ of nanoparticles gets miniaturised to ‘droplet-core synthesis’, which is being reported for the first time.
Highlights
Chitosan nanoparticles are biocompatible, relatively non-toxic, biodegradable, and cationic in nature[1,2]
The number of the hyphen should appear after nano increased with rising reaction temperature and time
It is clear from these data that an interplay of factors like temperature, time and concentration of reactants determines the size, distribution and the number of particles formed
Summary
Relatively non-toxic, biodegradable, and cationic in nature[1,2]. The number of the hyphen should appear after nano (nano-particles) increased with rising reaction temperature and time. It is clear from these data that an interplay of factors like temperature, time and concentration of reactants determines the size, distribution and the number of particles formed.
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