Abstract
The aim of this work was to perform an analysis of the influence of Sodium Fluoride (NaF) on chitosan particles size and morphology produced via ionotropic gelation with higher rotational stirring speed. Samples were characterized by Fourier Transform Infrared Spectroscopy (FTIR), Dynamic Light Scattering (DLS), Zeta Potential (ζ), Scanning Electron Microscopy and Energy Dispersive Spectroscopy (SEM/EDS). Chitosan/TPP particles diameter obtained was in the order of 3.8 µm. When NaF was added in different concentration (0.05%, 0.2% and 2%), the particle size diameter values, Zeta Potential and Poly Dispersive Index measures consequently decreased. Even so, no further modification in morphology was found. An exception was made for the samples with higher NaF concentration. After 21 days, occurred an increase in the particle size diameter. In the future, the proposed methodology could provide a dentistry application, especially on delivering particles of NaF.
Highlights
Chitosan nanoparticles and chitosan microparticles have been investigated in the past few years due to potential applications on medical and pharmaceutical fields[1] such as gene carriers, proteins[2,3,4], drugs, cancer diagnosis and treatment[5,6]
The aim of this work was to perform an analysis of the Sodium Fluoride (NaF) addition the influence on chitosan particles size and morphology produced via ionotropic gelation
The bands located at 1637 cm-1 and in 1549 cm-1 are attributed to the absorption of C=O, relative to the stretching of carbonyl groups (-NHCOCH3) and to the amine group (NH2), respectively, once the chitosan is not fully deacetylated
Summary
Chitosan nanoparticles and chitosan microparticles have been investigated in the past few years due to potential applications on medical and pharmaceutical fields[1] such as gene carriers, proteins[2,3,4], drugs, cancer diagnosis and treatment[5,6]. To produce chitosan particles in several different sizes, ionotropic gelation method is generally applied. This method consists of a reaction of protonated chitosan with multivalent polyanions. Chitosan jellifies rapidly as a consequence of the formation of inter- and intramolecular bonds between the chitosan amino group and multivalent polyanions. Different factors could influence particle size and distribution. Protonated amino groups from chitosan reacts with TPP ions, resulting in an ionotropic gelation reaction. A number of factors influencing this system has been proposed, such as solution concentration, chitosan / TPP ratio, pH, molecular weight[9,13] and mixing conditions (mechanical stirring or sonification)[14]
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