Abstract
An environmentally friendly method for the efficient synthesis of biologically active 1,4-dihydropyridine derivatives has been performed. The reaction was carried out under solvent-free conditions using chitosan magnetic nanocomposite of Ch-Rhomboclase as an efficient heterogeneous recyclable catalyst. The chitosan magnetic nanocomposite was synthesized through a comfortable and reasonably priced method. It was specified by FT-IR, XRD, EDS, SEM, TEM, VSM, and TGA analyses. Mild reaction conditions, absence of toxic solvent, low catalyst loading, high speed and efficiency, magnetically removable catalyst, and reusability of catalyst are the most important advantages of this method for the synthesis of Hantzsch 1,4-dihydropyridines.
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