Abstract
Chitosan/montmorillonite nanocomposite films were prepared by the solvent evaporation method to immobilize the drug ibuprofen (IBU) and delay its release in a medium that simulates the environment of the gastrointestinal tract. The effects of montmorillonite, at different mass proportions (10, 20, and 50%), on the morphological and physical properties of the films were studied. The samples were characterized by X-ray diffraction (XRD), Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), degree of swelling, drug encapsulation, and drug release efficiency. According to the XRD it was evidenced that the incorporation of montmorillonite to chitosan led to the formation of nanocomposites of ordered morphology. The infrared spectra confirmed the good interaction between montmorillonite and chitosan by the formation of nanocomposites. This fact, which favored the imprisonment of the IBU, reduced the diffusion coefficient in the studied systems. The micrographs comproved the formation of dense and uniform films. The controlled release profile, especially for the nanocomposite with 10% clay mass, showed a slow drug release rate. The incorporation of montmorillonite at different proportions produced different morphologies, with good encapsulation efficiency and an adequate profile for the controlled release of the drug.
Highlights
Clay-polymer nanocomposites have been being subject of study of multiple areas of knowledge
According to Tan et al (2008), it is possible that a bilayer of chitosan molecules has been intercalated between the layers of montmorillonite clay, since values referring to a basal interplanar distance (d001) around 2.02 nm indicate that chitosan bilayers were positioned between the montmorillonite layers
The value of ‘n’ indicated that they have suffered influence of the montmorillonite content used in the systems and that in phosphate buffer solution (PBS) pH 1.2 and 7.4 the release of the IBU from the films the chitosan/ibuprofen films (CS/IBUf), CS/50MMT/IBUf, CS/20MMT/IBUf and CS/10MMT/IBUf occurred by a Fick diffusion mechanism (n
Summary
Clay-polymer nanocomposites have been being subject of study of multiple areas of knowledge. These hybrids show interesting biomedical properties while produced with biopolymers, such as chitosan, associated with layered silicates (clay minerals) (Barbosa et al, 2018). Clay-biopolymer nanocomposites are a novel class of versatile materials with an expanding range of possible applications involving drug delivery systems and tissue engineering (Mukhopadhyay et al., 2020). Due to their cation exchange capacity and adsorptive potential, mineral clays can interact with drug molecules, facilitating their liberation. Ibuprofen (IBU), which is cationic in nature, can facilitate drug loading into interlayer regions of MMT and help to achieve adequate sustained-release (Manzoor et al., 2018)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
