Abstract
<p>Increasing accumulation of lead in body causes serious health problems. Chelation is widely used to decrease lead level in body. This research aims the effectivity of chitosan in chelating lead and their protective ability toward liver and kidney for lead acetate-induced rat. Thirty rats were divided into 6 treatment groups. All groups, except control group, were administered by 175 mgkg<sup>-1</sup> BW lead acetate. Positive control group was treated using EDTA 50 mgkg<sup>-1</sup> BW. Treatment group 1,2, and 3 were treated using chitosan in dose of 64, 32, and 16 mgkg<sup>-1 </sup>BW dissolved in 2% acetic acid, respectively in 30 days. The effectivity of chitosan was compared to blood lead level. ALT and AST level were measured to determine the protective ability of chitosan. Normal function of kidney was assessed using creatinine level. Results showed that blood lead level from all treatment groups, except negative control group, had no significant difference from control group. EDTA and chitosan ability in chelating lead were proven by low level of AST, ALT, and creatinine in treatment groups. This indicated that there was no significant difference from control group. Chitosan capable of chelating lead and protecting kidney and liver from heavy metal. </p><p> </p>
Highlights
Expanding industries causes increasing number of reported lead pollution incident from working environment
Around 51% of total workers in metal melting industry in Ceper, Klaten, has high blood lead level, surpassing quality standards assigned by NIOSH (Ambarwanto, et al, 2015)
Whereas chitosan-treated group has higher blood lead level compared to positive control and control group
Summary
Expanding industries causes increasing number of reported lead pollution incident from working environment. Chitosan ability in absorbing blood lead needs further examination, especially its comparative effectivity with EDTA, and its protective properties for liver and kidney in lead acetateexposed rat. Results of average blood lead level among treatment groups is shown below at Figure 1. Different results are shown by groups treated with chelating agents, which are chitosan and EDTA.
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