Abstract
The known biotechnological properties of chitosan and the recent biological activities attributed to polysaccharides from Agaricus brasiliensis have been of interest to obtain films constituted by these two polymers. The glucans obtained from the mushroom inhibited about 96.5% of the ferrous ion, besides not promoting a significant increase of lactate dehydrogenase enzyme (LDH), which indicates that the polysaccharide is able to inhibit the production of radical species and also presents low cytotoxicity to the biological systems. The results of spectroscopy analyses in the infrared region (FTIR) and X-ray diffraction suggest an existing electrostatic interaction between the substances. A reduction in the films’ swelling capacity was observed with an increase in the polysaccharide content in the composition. In addition, scanning electron microscopy (SEM) revealed greater surface density of the films. In convening the biological properties of the substances, it is expected that this study raises interest in evaluating the films and their capacity for healing wounds and burns.
Highlights
The use of films based on biopolymers in food packaging, wound covering and drug permeation systems have gained prominence in recent decades.[1,2,3] This fact is associated with their different biological properties, such as antimicrobial and antioxidant activity, wound healing and hemocompatibility.[4,5,6,7] they form biodegradable films with good mechanical characteristics, which would allow them to replace synthetic polymers.[8]Chitosan is one of the most studied polymers
The polymers isolated from the Agaricus brasiliensis mushroom presented about 96.5% of the ferrous ion chelation at concentrations of 1.0, 2.0 and 3.0 mg mL−1
Studies have shown that polysaccharides obtained from plants and fungi have demonstrated antioxidant activity, which may be justified by the presence of hydroxyl groups capable of stabilizing solitary electrons.[45]
Summary
The use of films based on biopolymers in food packaging, wound covering and drug permeation systems have gained prominence in recent decades.[1,2,3] This fact is associated with their different biological properties, such as antimicrobial and antioxidant activity, wound healing and hemocompatibility.[4,5,6,7] they form biodegradable films with good mechanical characteristics, which would allow them to replace synthetic polymers.[8]. Chitosan is one of the most studied polymers. Its use in films intended for wound healing can be justified because it is a biodegradable, non-toxic and biocompatible polymer and presents many biological activities. It has free amino groups capable of attacking electrophilic centers or interacting electrostatically with negatively charged groups in the acid medium forming crosslinks.[9,10,11,12,13]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
