Abstract
Hybrid hydrogel was fabricated by a classic sol-gel method using EDC/NHS as crosslink reagent grafting onto the thermoplastic polyurethane (TPU), nonwoven fabric, for controlled release of drug. In this study, precursor acetic acid (AA) was used to plasma deposit on the surface of TPU to form a hydrophilic thin film. Hybrid hydrogel was investigated through scanning electron microscopy (SEM), water contact angle (WCA) measurement, Fourier transform infra-red (FTIR) spectroscopy, UV/V is spectroscopy, equilibrium swelling ratio, MTT assay and drug delivery system studies. This polyelectrolyte complexes (PECs) formed hydrogel, pH-sensitive type, was evaluated at pH value of 1.2 and 7.4 of buffer solution and at temperature of 37C to observe its rate of swelling and drug release features with caffeine. Moreover, the mechanism of caffeine release from membrane devices (n=0.58) are anomalous transport, non-Fickian diffusion, the value of n lies between 0.43 and 0.85. It has an excellent release ratio up to about 90% absorption cumulative amounts of caffeine at pH 7.4 after 8h and could be a beneficial carrier for fragile drugs.
Highlights
In the 1950s, the first developed commercial thermoplastic polyurethane, TPU, was established in the U.S by B
Water contact angle (WCA) of TPU film was measured by the sessile drop method with distilled water at room temperature
After plasma deposition of acetic acid, at power of 40 W and 50mtorr for 30 minutes, WAC is 106.4°, demonstrated hydrophilic leaning was due to cover with acetic acid
Summary
In the 1950s, the first developed commercial thermoplastic polyurethane, TPU, was established in the U.S by B. TPU commonly made by polyol, diisocyanate and a chain extender. One is the soft block consists of polyester or polyether given their elastomeric and flexibility properties, another is the hard block built out of isocyanate and a chain extender offer TPU its high modulus, toughness and tensile strength. This nonwoven has some advantages such as vast surface area [1], transparent, weathering resistance [2], heat and aging resistance [3], elasticity [4], water-proof [5]
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