Abstract

Background: Chitinase -3-Like protein-1 (CHI3L1) is a glycoside secreted by monocytes, microglia, and activated astrocytes. Its distribution in inflammatory lesions suggests that it might be an important component of the astrocytic response to modulate CNS inflammation. CHI3L1 levels in CSF have been found to influence prognosis, disease severity and progression in multiple sclerosis (MS) patients.

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