Abstract
BackgroundIn guided bone regeneration (GBR) technique, many materials have been used for improving biological effectiveness by adding on membranes. The new membrane which was constructed with chitin-fibroin-hydroxyapatite (CNF/HAP) was compared with a collagen membrane (Bio-Gide®) by means of micro-computed tomography.MethodsFifty-four rats were used in this study. A critical-sized (8 mm) bony defect was created in the calvaria with a trephine bur. The CNF/HAP membrane was prepared by thermally induced phase separation. In the experimental group (n = 18), the CNF/HAP membrane was used to cover the bony defect, and in the control group (n = 18), a resorbable collagen membrane (Bio-Gide®) was used. In the negative control group (n = 18), no membrane was used. In each group, six animals were euthanized at 2, 4, and 8 weeks after surgery. The specimens were analyzed using micro-CT.ResultsBone volume (BV) and bone mineral density (BMD) of the new bone showed significant difference between the negative control group and membrane groups (P < 0.05). However, between two membranes, the difference was not significant.ConclusionsThe CNF/HAP membrane has significant effect on the new bone formation and has the potential to be applied for guided bone regeneration.
Highlights
In guided bone regeneration (GBR) technique, many materials have been used for improving biological effectiveness by adding on membranes
We reported the comparative study of a chitosan-fibroin-hydroxyapatite (CFB-HAP) membrane and collagen membrane for bone regeneration [7]
The purpose of this study is to compare the new bone formation and healing in rat skull defect using the new chitin-fibroin-hydroxyapatite membrane and collagen membrane (Bio-Gide®), which has been widely used at dental offices as a barrier membrane of guided bone regeneration, by means of computerized tomography analysis
Summary
In guided bone regeneration (GBR) technique, many materials have been used for improving biological effectiveness by adding on membranes. The new membrane which was constructed with chitin-fibroin-hydroxyapatite (CNF/HAP) was compared with a collagen membrane (Bio-Gide®) by means of micro-computed tomography. Guided bone regeneration (GBR) is a valuable procedure that uses a membrane to reconstruct bone defect in the oral and maxillofacial area [1]. Since first reported by Boyne [3], who used a cellulose acetate filter to regenerate bone in surgically created mandibular defect, numerous materials for the membrane. We reported the comparative study of a chitosan-fibroin-hydroxyapatite (CFB-HAP) membrane and collagen membrane for bone regeneration [7]. The CFB-HAP membrane showed significant potential as a guided bone regeneration membrane. Shi et al [8] reported that
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
