Chisocheton pentandrus (Blanco) Merr. leaf as a potential antioxidant and α-glucosidase inhibitory agent

Abstract

Indonesia is one of the countries with the highest diversity of plants worldwide, including the Chisocheton genus. The Chisocheton genus has been widely used in traditional medicine due to a variety of compounds with different activities, such as antiplasmodial, antiviral, and anti-inflammatory. The focus of this research is to determine the antioxidant, anti-diabetic, and anti-bacterial activity of Chisocheton pentandrus leaf extract from the Bali Botanic Garden plant collection, as well as the chemical compounds contained in the extract. The antioxidant activity test was carried out by capturing DPPH-free radicals, the antidiabetic test was carried out by assaying its inhibitory activity toward α-glucosidase enzyme, the antibacterial test was carried out using the agar diffusion method, while LC-MS/MS was used to determine the compounds contained in the extract. The results showed that the C. pentandrus leaf methanol extract showed the highest inhibitory activity as an antioxidant and inhibitor of the α-glucosidase enzyme in the very strong category; however, the extract is not effective in inhibiting bacterial growth.