Abstract
The origin of life, based on the homochirality of biomolecules, is a persistent mystery. Did life begin by using both forms of chirality, and then one of the forms disappeared? Or did the choice of homochirality precede the formation of biomolecules that could ensure replication and information transfer? Is the natural choice of L-amino acids and D-sugars on which life is based deterministic or random? Is the handedness present in/of the Universe from its beginning? The whole biosystem on the Earth, all living creatures are chiral. Many theories try to explain the origin of life and chirality on the Earth: e.g., the panspermia hypothesis, the primordial soup hypothesis, theory of parity violation in weak interactions. Additionally, heavy neutrinos and the impact of the fact that only left-handed particles decay, and even dark matter, all have to be considered.
Highlights
There is no doubt that rotational and geometric isomers significantly influence the biological activities of the corresponding compounds
The utmost important reason is that at the molecular level, the living matter is composed of chiral macromolecules—proteins, glycolipids, polynucleotides—which are formed of homochiral structural units of D-sugars and L-amino acids
The questions are: Did life begin by using both forms of chirality, and one of the forms disappeared? Or did the choice of homochirality precede the formation of biomolecules that could ensure replication and information transfer? Is the natural choice of L-amino acids and D-sugars on which life is based deterministic or random? Is the handedness in/of the Universe present from the times of the Big Bang? These secrets posed tantalizing questions for generations of researchers [1]
Summary
There is no doubt that rotational and geometric isomers significantly influence the biological activities of the corresponding compounds. There are many reasons for this, because most drugs and remedies whose biological activity depends on their stereochemistry are chiral. The utmost important reason is that at the molecular level, the living matter is composed of chiral macromolecules—proteins, glycolipids, polynucleotides—which are formed of homochiral (possessing the same sense of chirality) structural units of D-sugars and L-amino acids. The origin of the single chirality of most biomolecules is still a great puzzle. The questions are: Did life begin by using both forms of chirality, and one of the forms disappeared? Did the choice of homochirality precede the formation of biomolecules that could ensure replication and information transfer? Is the natural choice of L-amino acids and D-sugars on which life is based deterministic or random? The questions are: Did life begin by using both forms of chirality, and one of the forms disappeared? Or did the choice of homochirality precede the formation of biomolecules that could ensure replication and information transfer? Is the natural choice of L-amino acids and D-sugars on which life is based deterministic or random? Is the handedness in/of the Universe present from the times of the Big Bang? These secrets posed tantalizing questions for generations of researchers [1]
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