Abstract
AbstractIn enantioselective gas chromatography (enantio‐GC), the chiral stationary phases (CSPs) are coated on deactivated capillary columns in bulk as nonvolatile liquids or as solution in a conventional achiral stationary phase (squalane, polyethylene glycol, and various polysiloxanes). In Chirasil‐type CSPs, the chiral selector is chemically bonded to a polysiloxane backbone and thermally immobilized on the capillary inner surface. Three different approaches of mixed binary selector systems in enantio‐GC have been described in this chapter. The separation of enantiomers on chiral nonracemic selectors by enantio‐GC is entirely governed by thermodynamics. It is brought about by the fast and reversible formation of transient and energetically distinct diastereomeric association complexes (DD′ and LD′) between the select and enantiomers (arbitrarily denoted D and L) and the enantiopure selector (arbitrarily denoted D′). The chapter ends with a note on the mechanisms of chirality recognition.
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