Abstract
AbstractAn efficient access to chiral pyrrolidine derivatives bearing one trifluoromethylated quaternary stereogenic centers is developed through Cu(I)/(S)‐TF‐BiphamPhos‐catalyzed asymmetric 1,3‐dipolar cycloaddition of azomethine ylides with tert‐butyl 2‐(trifluoromethyl)acrylate in moderate to high yields, excellent diastereoselectivities and good enantioselectivities (up to 95% yield, >20 : 1 dr, 89% ee).
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