Chiral Thiophosphoramide and Thioamide Ligands in Catalytic Asymmetric Carbon-Carbon Bond-Formation Reactions

Abstract

Metal complexes with organosulfur ligands exist widely in nature. The high polarizability of the electrons on the sulfur atoms is responsible for a variety of structures and the reactivity of metal complexes with sulfur-containing ligands. Organosulfur-containing chiral ligands have various applications in catalytic asymmetric reactions. Our group has been interested in the applications of a series of thiophosphoramide and thioamide ligands in asymmetric carbon-carbon bond-formation reactions. In this account, we describe the synthesis of chiral thiophosphoramide and thioamide ligands and their applications in catalytic asymmetric carbon-carbon bond formation.