Abstract
Four novel alkaloid-lignan hybrids, lobechinenoids A–D (1–4), were isolated as a mixture of two diastereomeric pairs of enantiomers from the aerial parts of Lobelia chinensis. These compounds are constituted of the union of a tetrahydroisoquinoline alkaloid and a dihydrobenzofuran neolignan moiety. The structures were determined by detailed analyses of IR, MS and NMR data. These four compounds were characterized as two pairs of enantiomers by on-line chiral high performance liquid chromatography (HPLC)–circular dichroism (CD) analysis. The chiral HPLC separation was accomplished in the normal-phase mode using Chiralpak AD-H, a polysaccharide-derived chiral stationary phase (CSP) and a hexane-ethanol mobile phase. In order to study the chiroptical properties, all of the four single stereoisomers were successfully prepared on an analytical Chiralpak AD-H column and their stereochemical features were determined tentatively based on their CD spectra.
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