Abstract
Stripping crystallization (SC) is introduced in this work for chiral purification of R-phenylglycinol from the enantiomer mixture with an initial concentration ranging from 0.90 to 0.97. As opposed to the solid–liquid transformation in melt crystallization, the three-phase transformation occurs in SC at low pressures during the cooling process. SC combines melt crystallization and vaporization to produce a crystalline product and mixture vapor from a mixture melt due to the three-phase transformation. Thermodynamic calculations were applied to determine the operating pressure for the three-phase transformation during the cooling process in the SC experiments. To consider the possible deviations between the calculated and the actual three-phase transformation conditions, the product purity and the recovery ratio of R-phenylglycinol were investigated within a range of operating pressures during the cooling process.
Highlights
Pure enantiomer is often needed for the desired therapeutic effect due to different pharmacological and pharmacokinetic processes for the enantiomers of drugs
Stripping crystallization (SC) was successfully applied for chiral purification of R-phenylglycinol from the phenylglycinol enantiomers
A lower pressure during the cooling process generally led to a higher experimental product purity with a lower experimental recovery ratio
Summary
Pure enantiomer is often needed for the desired therapeutic effect due to different pharmacological and pharmacokinetic processes for the enantiomers of drugs. Chromatographic separation has been investigated extensively [7,8,9,10], the synthesis of efficient chiral stationary phases in chromatographic methods is usually deemed a robust technology. Enantioseparation, using extractant impregnated resins [14] or liquid–liquid extraction [15,16] has been proposed to separate R-Phenylglycinol from the racemic mixture. An enantioselective solvent is chosen and used as extractant for the enantioseparation of phenylglycinol. The thermodynamic calculations are to determine the threeobjective of this research is to study the feasibility of SC inadopted purification of R-phenylglycinol phase transformation conditions for the SC experiments. The effects of various operating conditions from a phenylglycinol mixture. R-phenylglycinol crystalline product are three-phase transformation for the SC of experiments
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