Chiral separation of amino acids using a chiral crown ether by impregnation on a polymeric support and monoamine modified silica gel

Abstract

A chiral monoaza-15-crown-5 ether derivative was prepared from l-Leucinol and used as a chiral stationary phase. The new chiral stationary phases CSP- 1 and CSP- 2 were employed in separating the enantiomers of the sodium and potassium salts of amino acids. The sodium and potassium salt of the d-enantiomers of all amino acids (PhyAlaNa, PhyAlaK and PhyGlyNa, PhyGlyK, and TrpNa, TrpK) show higher selectivity than the l-enantiomers for both CSP- 1 and CSP- 2.