Abstract
Enantiodiscrimination of ditryptophan enantiomers ( l-Trp- l-Trp and d-Trp- d-Trp, l-Trp- d-Trp and d-Trp- l-Trp) was observed in bio-membrane models, such as micellar aggregates of 1,2-diheptanoyl- sn-glycero-3-phospatidylcholine (DHPC) and multilamellar vesicles of either 1-palmitoyl-2-oleoyl- sn-glycero-3-phosphocholine (POPC) or 1,2-dimyristoyl- sn-glycero-3-phospatidylcholine (DMPC) by solution 1H NMR and HR-MAS 1H NMR, respectively. The attainment of resolved signals, allowed the first detection of enantiodiscrimination at a molecular level, and the identification of the site of chiral recognition and of the interactions and conformations of homo- and heterochiral dipeptides in large-sized aggregates formed by a common component of bio-membranes.
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