Chiral, Polyionic Dendrimers with Complementary Charges − Synthesis and Chiroptical Properties

Abstract

Chiral dendrimers up to the second generation have been prepared from enantiopure aromatic bis- and tris(amino acids) by peptide coupling techniques. The dendrimers could be deprotected to yield water-soluble polyamine and/or polycarboxylic acid macromolecules. Two complementary types, with respect to the charges carried in water at pH = 7, were synthesised. A chiroptical study of the protected dendrimers, which were soluble in THF and CHCl3, was conducted. The results of that study indicate that the solution shapes of these dendrimers are rather decongested, with little steric interaction between different parts of the dendritic structure.