Abstract
This work describes the desymmetrization of cyclohexadienones utilizing a chiral phosphoric acid 1 catalyzed intramolecular oxo-Michael addition. In the presence of 1 different cyclohexadienones cyclized readily to give the corresponding products in high yields and enantioselectivities. The versatility of this reaction was demonstrated in the asymmetric synthesis of three cleroindicin natural products.
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