Abstract
A new chiral auxilliary, (S)-N-(2,4,6-trimethylbenzyl)proline (2-benzoylphenyl)amide, has been synthesised as a potential building block for the preparation of chiral synthons of amino acids. The nickel(II) complex of its Schiff base derivative with glycine has been methylated with 97% d.e. (diastereomeric excess), whilst the nickel(II) complex of its Schiff base derivative with (RS)alanine has been 13C-methylated with 66% d.e.
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