Chiral N, N′-dioxide-iron(II) complexes catalyzed enantioselective oxa-Michael addition of α,β-unsaturated aldehydes

Abstract

The enantioselective oxa-Michael addition reaction of 1-(4-methoxyphenyl) ethanone oxime to various α,β-unsaturated aldehydes was accomplished by using chiral N, N′-dioxide-FeSO 4·7H 2O (1:1) complex. Aromatic acid was employed as additive to increase the yield of the reaction. The corresponding adducts were obtained in moderate yields with up to 76% ee under mild conditions.