Abstract
A new liquid chromatograpic method has been developed for the chiral separation of the enantiomers of bevantolol hydrochloride. The enantiomers were separated by a Chiralpak IB (250 × 4.6 mm, 5 µm) with a binary solvent mixture of acetonitrile—20 mmol · L−1 KH2PO4 (25/75, v/v; pH 4.5)—at 25°C and detected at 259 nm, with a flow rate of 0.8 mL · min−1. The resolution was 3.90. The effects that organic modifier, type of buffer, mobile phase pH, column temperature, and flow rate had on the enantioselectivity of enantiomers were evaluated. And the structures of the enantiomers of bevantolol hydrochloride were determined.
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