Chiral ferrocene cyanohydrin derivatives—access to novel intermolecularly linked and intramolecularly bridged ferrocene derivatives

Abstract

By reduction of the cyano group in ( R)-(cyanohydroxymethyl)ferrocene and ( R, R)-1,1′-bis(cyanohydroxymethyl)ferrocene, amines were obtained giving access to several new diamine and diamide bridged chiral ferrocene derivatives. As a representative for an intramolecularly bridged ferrocene compound bearing two chiral centres ( R, R)- 8 was obtained with excellent optical purity.