Abstract
The accurate chiral discrimination ofeach separated analyte has become an important task fortheir optical purity control and stereoselective pharmacokineticstudies in chiral drug development. The migration order ofseparated enantiomers is mainly determined by co-electro-phoresis with enantiomerically pure standards and matchingits migration time or relative migration time (RMT) with thatof the reference. However, crosschecking two RMT setsmeasured with two chiral selectors of different enantio-selectivities could enhance confidence in the identificationof CE peaks and the chiral discrimination as well. Based onthis concept, simultaneous chiral discrimination of 15racemic aromatic amino acids was achieved with chiral CEin neutral and charged cyclodextrin modes in our previousreport.
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