Chiral cysteine selective transport of proteins by CdS nanostructures modified anodic aluminum oxide template

Abstract

Protein transport is an important process of life and is strongly influenced by chiral interaction. But the study of protein transport mainly in biomimetic nanopores, and the application of nanomaterials in biological field only focus on sensors. Inspiring by the excellent property of artificial biomimetic nanochannels, we assembled CdS nanoparticles (CdS NPs) in anodic aluminum oxide (AAO) nanochannels and modified with cysteine enantiomers for bovine serum albumin (BSA) transport to study the improvement of sensitivity about nanomaterials in nanochannels. In addition, we chose a simplified geometric model to explore the BSA transport. The results show that CdS NPs self-assembled in AAO nanochannels and modified with chiral cysteine can improve the sensitivity of BSA response. The theoretical calculation validated CdS NPs self-assembled in AAO nanochannels how to improve the sensitivity of BSA response. This research presents a new application of nanomaterials in biological sensors and is supported by a theoretical calculation, which is meaningful for understanding the role of protein transport.