Abstract

The syntheses of both enantiomers of cyclobutanes B and ent-B are achieved through heteroatom-directed conjugate addition (HADCA) of nucleophiles to the epoxyvinylsulfone-substituted carbohydrates A and ent-A, which provided carbanions that intramolecularly attacked the epoxide with concomitant formation of the cyclobutane ring.

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