Chiral copper-salen complex grafted over functionalized mesoporous silica as an efficient catalyst for asymmetric Henry reactions and synthesis of the potent drug (R)-isoproterenol

Abstract

A new chiral Cu(ii)@AFS-1 catalyzed asymmetric Henry reaction (ee = 94%, yield 96%) and diastereoselective Henry reaction have been reported. Additionally, drug (R)-(−)-isoproterenol was synthesized using this protocol.