Abstract
Positive effects of the polymeric support on the performance of supported chiral catalysts, in terms of activity, stability and selectivity-enantioselectivity, have been reported when the support is properly selected and optimized opening the way to the design of more efficient catalytic systems.
Highlights
Introduction and scopeChirality plays a major role in chemistry
In the case of supported Ti-TADDOLates 62 (Fig. 10) prepared by grafting and studied for the Diels–Alder cycloaddition of cyclopentadiene and 3-crotonoyl-1,3-oxazolidin-2-one using a 10 : 1 catalyst dienophile ratio,[129,130] no clear rationale was given to explain the observed increase in activity, but the presence of changes in the mechanism can be envisaged, in particular taking into account the potential participation in this reaction of several complexes with different molecularities.[140]
Many additional examples of polymer supported chiral catalytic systems can be found in the literature, the examples presented here illustrate with clarity how the support is not an innocent partner and plays an essential role in defining the performance of these systems
Summary
Introduction and scopeChirality plays a major role in chemistry. The physicochemical and biological properties of enantiomeric compounds can significantly differ, for instance due to stereospecific interactions with enzymes and receptors in biological systems.
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