Abstract
E-mail: lixiaoyun06@126.comReceived October 29, 2013, Accepted February 22, 2014The enantioselective α-chlorination of cyclic β-ketoesters catalyzed by chiral 2-aminoalcohol derivatives (2f)has been developed. For the optically active α-chlorinated products, the isolated yields are in the range of 85-94% and the enantiomeric excesses are up to 84% ee.Key Words : Enantioselective α-chlorination, 2-Aminoalcohol derivatives, β-KetoestersIntroductionThe enantioselective construction of C-X stereogenicityhas gained considerable momentum in modern organic syn-thesis, drug, discovery and sciences.
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