Abstract
Diabetic peripheral neuropathy (DPN) is one of the most common complications of chronic diabetes mellitus. Pathological characteristics of DPN include axonal atrophy, nerve demyelination, and delayed regeneration of peripheral sensory nerve fibers. The goal of treatment in DPN is not only to ameliorate neurological symptoms but also to slow or reverse the underlying neurodegenerative process. Schwann cells and neurotrophic factors play important roles in the repair and regeneration of peripheral nerves. The present paper reviews current studies and evidence regarding the neurological effects of traditional Chinese medicine, with an emphasis on recent developments in the area of nerve repair and regeneration in DPN.
Highlights
Diabetic peripheral neuropathy (DPN) is a common complication of chronic diabetes
Promoted proliferation of Schwann “Can promote the proliferation of MTT assay for proliferation of cells and increased expression of Schwann cells and increase the nerve growth factor (NGF) of Schwann cells cultured in expression of NGF of Schwann cells high glucose cultured in high glucose”
Lower HbA1c level in diabetic rats, inhibit Schwann cells apoptosis; the mechanism might be related to its inhibition of caspase-3 and Bax expression, and promoting the expression of Bcl-2”
Summary
Diabetic peripheral neuropathy (DPN) is a common complication of chronic diabetes. Pathological characteristics of DPN include axonal atrophy, nerve demyelination, and delayed regeneration of peripheral sensory nerve fibers. From the viewpoint of TCM [1], the etiology and pathogenesis of DPN are as follows: (1) with an increased duration of disease in diabetes, a deficiency of yin burns body fluid and blood, resulting in empty heat This increases blood viscosity, resulting in blood stasis, as well as blockage of sinews and channels; (2) excessive intake of foods high in fat and sugar content results in the deficiency of spleen and stomach, resulting in the accumulation of dampness and phlegm, which has a synergistic effect with stasis; (3) sinew and channels demonstrate poor nourishment because of the deficiency of liver and kidney; (4) the deficiency of yin results in a deficiency of yang, which generates an inner cold that results in microvascular coagulation. A total of 21 peer-reviewed papers written in Chinese were included in this paper
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