Abstract
Siwu-Yin (SWY), a traditional Chinese medicinal formula, can replenish blood and nourish Yin. It was recorded in ancient Chinese medicine books in treating esophageal dysphagia, which has similar symptoms and prognosis with esophageal precancerous lesions and esophageal cancer. However, its effect has not been established in vivo. This study explores the antiesophageal cancer effect of SWY on rats with esophageal precancerous lesions. By performing 16S rRNA gene sequencing and metabolomics, it was suggested that SWY may improve the composition of intestinal flora of rats by regulating the synthesis and secretion of bile acids. In addition, flow cytometry results showed that SWY treatment modified tumor microenvironment by improving macrophage polarization and therefore inhibiting the occurrence of esophageal precancerous lesions.
Highlights
Traditional Chinese medicine (TCM) has several thousand years of history
The results show that the enrichment of Turicibacteraceae and Turicibacter in intestinal flora of esophageal precancerous lesion model rats was significantly lower than that of normal rats, and SWY could increase the abundance of Turicibacteraceae and Turicibacter
SWY, as a TCM formula, has been used to treat esophageal precancerous lesions mainly based on ancient Chinese medical literature
Summary
Traditional Chinese medicine (TCM) has several thousand years of history. It is mainly derived from nature, such as botanical drug medicine and insect medicine. TCM has a good reputation and extensive clinical application in modern Chinese society, the evaluation of its effects is often based on the self-perception of patients and lacks laboratory scientific certification or high-level clinical trials. The region surrounding the Taihang Mountains is one of the areas that have the highest incidence of esophageal cancer in China (Totsuka et al, 2019). Through long-term clinical experience and thorough observations, the clinical doctors in our research group found that most patients with esophageal cancer had symptoms of dry mouth, constipation, and weight loss, and treatment using TCM for supplementing blood and nourishing Yin achieved remarkable results in the management of esophageal cancer (Shi et al, 2016; Kong et al, 2019).
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