Abstract
Killer cell lectin-like receptor G1 (KLRG1) is a C-type lectin inhibitory receptor that contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic domain. KLRG1 is well conserved in mammals and is mostly expressed on subsets of T cells and natural killer (NK) cells. Upon binding to its ligands, N-cadherin and E-cadherin, the phosphatases SHP-2 and SHIP-1 are recruited to the cytoplasmic tail of KLRG1. Some studies have proposed that KLRG1 is a marker of senescence, while other studies suggest that KLRG1 is a marker of recently activated cells. In addition, although KLRG1 inhibitory potential has been established <i>in vitro</i>, it is unclear whether KLRG1 inhibits NK cells and CD8<sup>+</sup> T cells <i>in vivo</i>. To address its exact role, we have used CRISPR technology to generate mice deficient for KLRG1 and mice conditionally deficient for KLRG1 in the NK cell lineage. We found that NK cell frequency and number is not effected and that NK cell development is globally intact in KLRG1 deficient mice. The role of KLRG1 during viral infections and tumor development is currently being investigated.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
